Bilirubin (Conj)

RT520  |   Global Clinical Trials  |  

Clinical significance

Bilirubin is the major product of hemoglobin catabolism. Formed in reticuloendothelial cells, bilirubin is bound to albumin and transported to the liver, where it is conjugated with glucuronide and excreted in the bile. Effective conjugation and excretion of bilirubin depends on a properly functioning hepatobiliary system and a normal red blood cell turnover rate. Measurements of serum conjugated (direct) bilirubin levels are useful in evaluating hepatobiliary and erythropoietic functions. Elevated conjugated bilirubin levels in the bloodstream are a very sensitive indicator of hepatocellular disease and biliary obstruction.

Sample type

SERUM

Minimum volume

0.5 mL

Reporting units

mg/dL

Minimum detection

0.1 mg/dL

Instrument platform

Roche Modular analyzer

Methodology

Roche reagent: Jendrassik-Grof method

Sample stability

Ambient: 24 hours // 2-8 degrees C: 7 days // -20 degrees C: 3 months

Reference ranges

< 0.4 mg/dL

Routine shipping

Ambient or Cold Pak