Fructosamine (T047) [Back]
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| RISK ASSESSMENT VALUE: |
Circulating serum proteins are glycosylated by a non-enzymatic mechanism. The extent of glycosylation is dependent on a number of variables, but the one of key importance is the average serum glucose concentration. The higher the average glucose concentration, the higher the concentration of glycosylated protein in the serum. When glucose is attached to protein it undergoes a structural rearrangement and forms a chemical called fructosamine. This is the compound that is measured in the assay.
The main protein gycosylated is albumin and because it has a ½ life of days, the period measured is the past 2-3 weeks which is substantially shorter than with HgA1c.
Though fructosamine is a useful screen because it is much less expensive to perform as compared to HgA1c, it suffers from limited sensitivity and specificity as compared to HgA1c because of the nature of the test. Rather than use fructosamine as a screen, the Glycated Protein (AGP) test measures much the same thing for only slightly higher cost but has better performance characteristics yielding higher sensitivity and specificity and better correlation with HgA1c.
Fructosamine values may be lowered in the presence of hypoalbuminemia. Low values were also observed in hyperthyroid patients (increased albumin turnover).
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| NORMAL RESULTS: |
1.2 - 2.1 mmol/L
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| ABNORMAL RESULTS: |
Values >2.1 mmol/L suggest elevated average glucose values and should reflex to HgA1c.
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| ADDITIONAL TESTS: |
HgA1c
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| SAMPLE NEEDED: |
Separated serum from a red-stopper tube
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| SAMPLE STABILITY: |
10 days at room temperature, 2 weeks when refrigerated, indefinitely when frozen.
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| METHOD & INSTRUMENT: |
Colorimetric test based on the ability of ketomines to reduce NBT. The level of reduction is directly proportional to fructosamine concentration. Hitachi Modular
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| INTERFERING FACTORS: |
Values are lower in the presence of high levels of ascorbic acid.
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| PURPOSE: |
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| PROFILE INCLUDES: |
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| RISK RANGE & UNITS: |
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