Alpha Fetoprotein (AFP) (T092) [Back]
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| RISK ASSESSMENT VALUE: |
Alpha fetoprotein is an albumin-like glycoprotein with a molecular weight of 70,000 D, is formed in the yolk sac, non-differentiated liver cells and the fetal gastro-intestinal tract. Seventy to ninety-five percent of patient with primary hepatocellular carcinoma have elevated AFP values. The later stage of non-seminomatous germ cell tumors, the higher the AFP values. Human hCG and AFP are important parameters for estimating the survival rate of patients with advanced, non-seminomatous germ cell tumors. No correlation between the AFP concentration and tumor size, tumor growth, stage or degree of malignancy has so far been demonstrated.
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| NORMAL RESULTS: |
Adults: less than 15 ng/ml. In pregnant women: the normal level is computed based on gestational age, mothers's age, mother's weight, presence of a multiple pregnancy, etc.
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| ABNORMAL RESULTS: |
Increased AFP levels in non-pregnant persons: Hepatocellular carcinoma, germ cell tumor of gonadal, retroperitoneal, or mediastinal origin Ataxia-telangiectasia, occasionally, cancer of the pancreas, stomach or biliary system.
Slightly increased AFP levels in norpregnant persons: Acute or chroninc hepatitis, alcohol cirrhosis.
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| ADDITIONAL TESTS: |
Checkup with physician.
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| SAMPLE NEEDED: |
Separated serum from red or mottled stopper tube.
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| SAMPLE STABILITY: |
Stable for 7 days when refrigerated, 3 months frozen. Avoid freezing and thawing.
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| METHOD & INSTRUMENT: |
Immunoassay, Roche E-170.
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| INTERFERING FACTORS: |
Hemolysis caused by rough handling of the sample or delayed centrifugation may alter AFP levels.
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| PURPOSE: |
To monitor the effectiveness of therapy in malignant conditions, such as hepatomas and germ cell tumors, and in certain nonmalignant conditions, such as ataxia-telangiectasia.
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| PROFILE INCLUDES: |
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| RISK RANGE & UNITS: |
0-7.9 ng/ml
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